Test Catalog

Test ID: CCBF    
Cell Count and Differential, Body Fluid

Useful For Suggests clinical disorders or settings where the test may be helpful

Aids in the diagnosis of joint disease, systemic disease, inflammation, malignancy, infection, and trauma, using body fluid specimens

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

When abnormal cytologic features are present, the laboratory may reflex to a miscellaneous cytology test. Fee codes for that test vary depending on review process.

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Body fluids, other than the commonly analyzed urine and blood, include synovial, pleural, peritoneal, and pericardial fluids. These fluids may be present in increased volumes and may contain increased numbers of normal and abnormal cells in a variety of disease states.

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.


Synovial fluid: <150/mcL

Peritoneal/pleural/pericardial fluid: <500/mcL



Synovial Fluid: <25%

Peritoneal/pleural/pericardial fluid: <25%



Synovial fluid: <75%



Synovial fluid: < or =70%

Interpretation Provides information to assist in interpretation of the test results

Trauma and hemorrhage may result in increased red and white blood cells; RBCs predominate. WBCs are increased in inflammatory and infectious processes:

-Neutrophils predominate in bacterial infections

-Lymphocytes predominate in viral infections

-Macrophages may be increased in inflammatory and infectious processes

-Eosinophils may be increased in parasitic or fungal infections

Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

No significant cautionary statements

Clinical Reference Recommendations for in-depth reading of a clinical nature

1. Kjeldsberg C, Knight J: Body Fluids: Laboratory examination of cerebrospinal, seminal, serous and synovial fluids. American Society of Clinical Pathologists, 1993

2. Dyken PR, Shirley S, Trefz J, El Gammel T: Comparison of cyto-centrifugation and sedimentation techniques for CSF cyto-morphology. Acta Cytologica 1980;20:137-170

3. Sheth KV: Cerebrospinal and body fluid cell morphology through a hematologist's microscope, workshop presented at the ASCP-CAP Joint Spring Meeting, San Diego, March 1981

4. Schumacher AH, Reginato A: Atlas of Synovial Fluid Analysis and Crystal Identification. Lea and Febiger, 1991

5. Hussong JW, Kjeldsberg CR: Kjeldsberg's Body Fluid Analysis. First edition. ASCP Press 2015