Web: | mayocliniclabs.com |
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Email: | mcl@mayo.edu |
Telephone: | 800-533-1710 |
International: | +1 855-379-3115 |
Values are valid only on day of printing. |
Aiding in the diagnosis of monoclonal gammopathies, when used in conjunction with free light chain studies
This test alone is not considered an adequate screen for monoclonal gammopathies
This test includes M-protein isotyping. If a light chain is identified without a corresponding heavy chain during initial testing, immunofixation with IgD and IgE antisera will be performed at an additional charge.
Immunotyping of monoclonal (M-) proteins identifies the monoclonal immunoglobulin heavy chain type (gamma, alpha, mu, delta, or epsilon) and light chain type (kappa or lambda) in serum specimens.
Only orderable as part of a profile. For more information see:
SPISO / Protein Electrophoresis and Isotype, Serum
SMOGA / Monoclonal Gammopathy Screen, Serum
MMOGA / Monoclonal Gammopathy Monitoring, Serum
No monoclonal protein detected
A characteristic monoclonal band (M-spike) is often found on serum protein electrophoresis (SPE) in the gamma globulin region and, more rarely, in the beta or alpha-2 regions. The finding of an M-spike, restricted migration, or hypogammaglobulinemic protein electrophoresis pattern is suggestive of a possible monoclonal protein.
Immunoaffinity purification followed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is performed to identify the immunoglobulin heavy and light chains.
No significant cautionary statements
Mills JR, Kohlhagen MC, Dasari S, et al: Comprehensive assessment of M-proteins using nanobody enrichment coupled to MALDI-TOF mass spectrometry. Clin Chem 2016;62(10):1334-1344