Test Catalog

Test ID: PBRCR    
Lead/Creatinine Ratio, Random, Urine

Useful For Suggests clinical disorders or settings where the test may be helpful

Detecting clinically significant lead exposure, a toxic heavy metal, in random urine specimens

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Increased urine lead concentration per gram of creatinine indicates significant lead exposure. Measurement of urine lead concentration per gram of creatinine before and after chelation therapy have been used as an indicator of significant lead exposure. An increase in lead concentration per gram of creatinine in the postchelation specimen of up to 6 times the concentration in the prechelation specimen is normal.

 

Blood lead is the best clinical correlate of toxicity.

 

For additional information, see PBBD / Lead with Demographics, Blood.

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

0-17 years: not established

> or =18 years: <2 mcg/g creatinine

Interpretation Provides information to assist in interpretation of the test results

Urinary excretion of less than 4 mcg/g creatinine is not associated with any significant lead exposure.

 

Urinary excretion greater than 4 mcg/g creatinine is usually associated with pallor, anemia, and other evidence of lead toxicity.

Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

This test is not a substitute for blood lead screening.

Clinical Reference Recommendations for in-depth reading of a clinical nature

1. Kosnett MJ, Wedeen RP, Rotherberg SJ, et al: Recommendations for medical management of adult lead exposure. Environ Health Perspect 2007;115:463-471

2. De Burbane C, Buchet JP, Leroyer A, et al: Renal and neurologic effects of cadmium, lead, mercury, and arsenic in children: evidence of early effects and multiple interactions at environmental exposure levels. Environ Health Perspect 2006;114:584-590

Special Instructions Library of PDFs including pertinent information and forms related to the test